Title:	Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination
Authors:	Tomášová, Petra Bugáňová, Martina Pelantová, Helena Holubová, Martina Šedivá, Blanka Železná, Blanka Haluzík, Martin Maletínská, Lenka Kuneš, Jaroslav Kuzma, Marek
Citation:	TOMÁŠOVÁ, P., BUGÁŇOVÁ, M., PELANTOVÁ, H., HOLUBOVÁ, M., ŠEDIVÁ, B., ŽELEZNÁ, B., HALUZÍK, M., MALETÍNSKÁ, L., KUNEŠ, J., KUZMA, M. Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination. Applied biochemistry and biotechnology, 2018, roč. 188, č. 1, s. 165-184. ISSN 0273-2289.
Issue Date:	2018
Publisher:	Springer
Document type:	článek article
URI:	2-s2.0-85056076757 http://hdl.handle.net/11025/35555
ISSN:	0273-2289
Keywords in different language:	Mass spectrometry;Metabolomics;Diet-induced obese mice;Plasma;Vildagliptin;Metformin
Abstract in different language:	Type 2 diabetes mellitus (T2DM) is a major epidemiological problem. Metformin and vildagliptin are well-established antidiabetic drugs. The aim of the study was to evaluate the changes of plasma metabolic profile induced by a high-fat diet (HFD) and subsequent oral administration of metformin, vildagliptin, and their combination in a mouse model of diet-induced obesity (DIO)/T2DM analyzed using quadrupole-time-of-flight mass spectrometry (qTOF-MS). Metformin treatment increased the levels of butyrylcarnitine and acylcarnitine C18:1 concentrations and decreased the levels of isoleucine concentrations compared to untreated HFD mice. Vildagliptin treatment increased levels of butyrylcarnitine and acetylcarnitine. In summary, our metabolomics study revealed multiple differences between obese diabetic HFD mice and lean standard chow diet (SCD) mice, which were partially modifiable by subsequent metformin and vildagliptin treatment.
Rights:	Plný text není přístupný. © Springer
Appears in Collections:	Články / Articles (KMA) OBD

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