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dc.contributor.authorTomášová, Petra
dc.contributor.authorBugáňová, Martina
dc.contributor.authorPelantová, Helena
dc.contributor.authorHolubová, Martina
dc.contributor.authorŠedivá, Blanka
dc.contributor.authorŽelezná, Blanka
dc.contributor.authorHaluzík, Martin
dc.contributor.authorMaletínská, Lenka
dc.contributor.authorKuneš, Jaroslav
dc.contributor.authorKuzma, Marek
dc.date.accessioned2019-10-21T10:00:15Z-
dc.date.available2019-10-21T10:00:15Z-
dc.date.issued2018
dc.identifier.citationTOMÁŠOVÁ, P., BUGÁŇOVÁ, M., PELANTOVÁ, H., HOLUBOVÁ, M., ŠEDIVÁ, B., ŽELEZNÁ, B., HALUZÍK, M., MALETÍNSKÁ, L., KUNEŠ, J., KUZMA, M. Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination. Applied biochemistry and biotechnology, 2018, roč. 188, č. 1, s. 165-184. ISSN 0273-2289.en
dc.identifier.issn0273-2289
dc.identifier.uri2-s2.0-85056076757
dc.identifier.urihttp://hdl.handle.net/11025/35555
dc.format20 s.cs
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartofseriesApplied Biochemistry And Biotechnologyen
dc.rightsPlný text není přístupný.cs
dc.rights© Springeren
dc.titleMetabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combinationen
dc.typečlánekcs
dc.typearticleen
dc.rights.accessclosedAccessen
dc.type.versionpublishedVersionen
dc.description.abstract-translatedType 2 diabetes mellitus (T2DM) is a major epidemiological problem. Metformin and vildagliptin are well-established antidiabetic drugs. The aim of the study was to evaluate the changes of plasma metabolic profile induced by a high-fat diet (HFD) and subsequent oral administration of metformin, vildagliptin, and their combination in a mouse model of diet-induced obesity (DIO)/T2DM analyzed using quadrupole-time-of-flight mass spectrometry (qTOF-MS). Metformin treatment increased the levels of butyrylcarnitine and acylcarnitine C18:1 concentrations and decreased the levels of isoleucine concentrations compared to untreated HFD mice. Vildagliptin treatment increased levels of butyrylcarnitine and acetylcarnitine. In summary, our metabolomics study revealed multiple differences between obese diabetic HFD mice and lean standard chow diet (SCD) mice, which were partially modifiable by subsequent metformin and vildagliptin treatment.en
dc.subject.translatedMass spectrometryen
dc.subject.translatedMetabolomicsen
dc.subject.translatedDiet-induced obese miceen
dc.subject.translatedPlasmaen
dc.subject.translatedVildagliptinen
dc.subject.translatedMetforminen
dc.identifier.doi10.1007/s12010-018-2899-8
dc.type.statusPeer-revieweden
dc.identifier.document-number467534600013
dc.identifier.obd43926021
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