Název:	Geometrical model of lobular structure and its importance for the liver perfusion analysis
Autoři:	Rohan, Eduard Camprová Turjanicová, Jana Liška, Václav
Citace zdrojového dokumentu:	ROHAN, E. CAMPROVÁ TURJANICOVÁ, J. LIŠKA, V. Geometrical model of lobular structure and its importance for the liver perfusion analysis. PLoS One, 2021, roč. 16, č. 12, s. 1-21. ISSN: 1932-6203
Datum vydání:	2021
Nakladatel:	Public Library of Science
Typ dokumentu:	článek article
URI:	2-s2.0-85120714787 http://hdl.handle.net/11025/47018
ISSN:	1932-6203
Klíčová slova v dalším jazyce:	geometrical model, liver tissue, hepatic lobulus, blood microcirculation, multi-scale modelling
Abstrakt v dalším jazyce:	A convenient geometrical description of the microvascular network is necessary for computationally efficient mathematical modelling of liver perfusion, metabolic and other physiological processes. The tissue models currently used are based on the generally accepted schematic structure of the parenchyma at the lobular level, assuming its perfect regular structure and geometrical symmetries. Hepatic lobule, portal lobule, or liver acinus are considered usually as autonomous functional units on which particular physiological problems are studied. We propose a new periodic unit - the liver representative periodic cell (LRPC) and establish its geometrical parametrization. The LRPC is constituted by two portal lobulae, such that it contains the liver acinus as a substructure. As a remarkable advantage over the classical phenomenological modelling approaches, the LRPC enables for multiscale modelling based on the periodic homogenization method. Derived macroscopic equations involve so called effective medium parameters, such as the tissue permeability, which reflect the LRPC geometry. In this way, mutual influences between the macroscopic phenomena, such as inhomogeneous perfusion, and the local processes relevant to the lobular (mesoscopic) level are respected. The LRPC based model is intended for its use within a complete hierarchical model of the whole liver. Using the Double-permeability Darcy model obtained by the homogenization, we illustrate the usefulness of the LRPC based modelling to describe the blood perfusion in the parenchyma.
Práva:	© authors
Vyskytuje se v kolekcích:	Články / Articles (KME) OBD

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