Title: Computer-assisted analysis of in-vitro vasculogenesis and angiogenesis processes
Authors: Lamberti, Fabrizio
Gamba, Andrea
Montrucchio, Bartolomeo
Citation: Journal of WSCG. 2004, vol. 12, no. 1-3, p. 237-244.
Issue Date: 2004
Publisher: UNION Agency
Document type: článek
URI: http://wscg.zcu.cz/wscg2004/Papers_2004_Full/M37.pdf
ISSN: 1213-6972
Keywords: vaskulogeneze;angiogeneze;analyzační systémy;segmentace obrazu
Keywords in different language: vasculogenesis;angiogenesis;analysis systems;image segmentation
Abstract: In recent years many experimental investigations have been carried out on vasculogenesis and angiogenesis, the mechanisms of blood vessels formation. Neovascularization is a hallmark of embryogenesis and many other physiological processes, such as wound healing or endometrium vascularization during the mestrual cycle. Angiogenesis also plays a key role in tumor growth, tumor metastasis and other pathological processes including many inflammatory diseases. Understanding biological phenomena regulating angiogenesis is therefore essential for clinical treatment of cancer and other angiogenesis-dependent diseases. This paper describes the development of a fully-automated computerized angiogenesis analysis system, which enables angiogenesis parameters to be quantified in an in-vitro model. The proposed methodology works on phase contrast microscopy snap photographs of cultured endothelial cell plates, and extracts a detailed graph-based representation of the blood vessels network thus supporting accurate angiogenesis parameters measurement.
Rights: © UNION Agency
Appears in Collections:Volume 12, number 1-3 (2004)

Files in This Item:
File Description SizeFormat 
M37.pdf682,87 kBAdobe PDFView/Open

Please use this identifier to cite or link to this item: http://hdl.handle.net/11025/1844

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.