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dc.contributor.authorKostovcikova, Klara
dc.contributor.authorCoufal, Stepan
dc.contributor.authorGalanova, Natalie
dc.contributor.authorFajstova, Alena
dc.contributor.authorHudcovic, Tomas
dc.contributor.authorKostovcik, Martin
dc.contributor.authorProchazkova, Petra
dc.contributor.authorJiraskova Zakostelska, Zuzana
dc.contributor.authorCermakova, Martina
dc.contributor.authorŠedivá, Blanka
dc.contributor.authorKuzma, Martin
dc.contributor.authorTlaskalova-Hogenova, Helena
dc.contributor.authorKverka, Miloslav
dc.date.accessioned2019-07-08T10:00:13Z-
dc.date.available2019-07-08T10:00:13Z-
dc.date.issued2019
dc.identifier.citationKOSTOVCIKOVA, K., COUFAL, S., GALANOVA, N., FAJSTOVA, A., HUDCOVIC, T., KOSTOVCIK, M., PROCHAZKOVA, P., JIRASKOVA ZAKOSTELSKA, Z., CERMAKOVA, M., ŠEDIVÁ, B., KUZMA, M., TLASKALOVA-HOGENOVA, H., KVERKA, M. Diet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Mice. Frontiers in Immunology, 2019, roč. 10, č. 26 April 2019, s. 1-14. ISSN 1664-3224.en
dc.identifier.issn1664-3224
dc.identifier.uri2-s2.0-85066948088
dc.identifier.urihttp://hdl.handle.net/11025/34865
dc.format14 s.cs
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.rights© Frontiers Mediaen
dc.titleDiet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Miceen
dc.typečlánekcs
dc.typearticleen
dc.rights.accessopenAccessen
dc.type.versionpublishedVersionen
dc.description.abstract-translatedDiet is a major factor determining gut microbiota composition and perturbances in this complex ecosystem are associated with the inflammatory bowel disease (IBD). Here, we used gnotobiotic approach to analyze, how interaction between diet rich in proteins and gut microbiota influences the sensitivity to intestinal inflammation in murine model of ulcerative colitis. We found that diet rich in animal protein (aHPD) exacerbates acute dextran sulfate sodium (DSS)-induced colitis while diet rich in plant protein (pHPD) does not. The deleterious effect of aHPD was also apparent in chronic DSS colitis and was associated with distinct changes in gut bacteria and fungi. Therefore, we induced acute DSS-colitis in germ-free mice and transferred gut microbiota from aCD or aHPD fed mice to find that this effect requires presence of microbes and aHPD at the same time. The aHPD did not change the number of regulatory T cells or Th17 cells and still worsened the colitis in immuno-deficient RAG2 knock-out mice suggesting that this effect was not dependent on adaptive immunity. The pro-inflammatory effect of aHPD was, however, abrogated when splenic macrophages were depleted with clodronate liposomes. This treatment prevented aHPD induced increase in colonic Ly-6Chigh pro-inflammatory monocytes, but the ratio of resident Ly-6C−/low macrophages was not changed. These data show that the interactions between dietary protein of animal origin and gut microbiota increase sensitivity to intestinal inflammation by promoting pro-inflammatory response of monocytes.en
dc.subject.translateddietary proteinen
dc.subject.translatedmicrobiota, colitisen
dc.subject.translatedgerm-freeen
dc.subject.translatedmacrophageen
dc.identifier.doi10.3389/fimmu.2019.00919
dc.type.statusPeer-revieweden
dc.identifier.document-number465743800002
dc.identifier.obd43926024
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