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dc.contributor.authorDekojová, Tereza
dc.contributor.authorHoudová, Lucie
dc.contributor.authorFatka, Jiří
dc.contributor.authorPitule, Pavel
dc.contributor.authorOstašov, Pavel
dc.contributor.authorCaputo, Valentina S.
dc.contributor.authorGmucová, Hana
dc.contributor.authorLysák, Daniel
dc.contributor.authorJindra, Pavel
dc.contributor.authorHolubová, Monika
dc.date.accessioned2021-03-15T11:00:27Z-
dc.date.available2021-03-15T11:00:27Z-
dc.date.issued2020
dc.identifier.citationDEKOJOVÁ, T. HOUDOVÁ, L. FATKA, J. PITULE, P. OSTAŠOV, P. CAPUTO, VS. GMUCOVÁ, H. LYSÁK, D. JINDRA, P. HOLUBOVÁ, M.Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study. Journal of Clinical Medicine, 2020, roč. 9, č. 11. ISSN 2077-0383.cs
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/11025/42924
dc.format13 s.cs
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherMDPIen
dc.relation.ispartofseriesJournal of Clinical Medicineen
dc.rights© MDPIen
dc.titleDynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Studyen
dc.typečlánekcs
dc.typearticleen
dc.rights.accessopenAccessen
dc.type.versionpublishedVersionen
dc.description.abstract-translatedKiller-immunoglobulin-like receptors (KIRs) are critical natural killer (NK) cell regulators. The expression of KIRs is a dynamic process influenced by many factors. Their ligands—HLA(Human Leukocyte Antigen) class I molecules—are expressed on all nucleated cells that keep NK cells under control. In hematopoietic stem cell transplantation (HSCT), NK cells play an essential role in relapse protection. In the presented pilot study, we characterized the dynamic expression of inhibitory KIRS (iKIRs), which protect cells against untoward lysis, in donors and patients during the first three months after HSCT using flow cytometry. The expression of all iKIRs was highly variable and sometimes correlated with patients’ clinical presentation and therapy regiment. Cyclophosphamide (Cy) in the graft-versus-host disease (GvHD) prevention protocol downregulated KIR2DL1 to just 25% of the original donor value, and the FEAM (Fludarabine + Etoposid + Ara-C + Melphalan) conditioning protocol reduced KIR2DL3. In lymphoid neoplasms, there was a slightly increased KIR2DL3 expression compared to myeloid malignancies. Additionally, we showed that the ex vivo activation of NK cells did not alter the level of iKIRs. Our study shows the influence of pre- and post-transplantation protocols on iKIR expression on the surface of NK cells and the importance of monitoring their cell surface.en
dc.subject.translatedKIRsen
dc.subject.translatedNK cellsen
dc.subject.translatedHSCTen
dc.identifier.doi10.3390/jcm9113502
dc.type.statusPeer-revieweden
dc.identifier.document-number593182400001
dc.identifier.obd43930593
dc.project.IDNV18-03-00277/Míra polymorfizmů v NK receptorech a jejich ligandech v rámci české populacecs
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