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dc.contributor.authorTomášová, Petra
dc.contributor.authorČermáková, Martina
dc.contributor.authorPelantová, Helena
dc.contributor.authorVecka, Marek
dc.contributor.authorKratochvílová, Helena
dc.contributor.authorLipš, Michal
dc.contributor.authorLindner, Jaroslav
dc.contributor.authorIvák, Peter
dc.contributor.authorNetuka, Ivan
dc.contributor.authorŠedivá, Blanka
dc.contributor.authorHaluzík, Martin
dc.contributor.authorKuzma, Marek
dc.date.accessioned2021-06-14T14:21:54Z-
dc.date.available2021-06-14T14:21:54Z-
dc.date.issued2020
dc.identifier.citationTOMÁŠOVÁ, P., ČERMÁKOVÁ, M., PELANTOVÁ, H., VECKA, M., KRATOCHVÍLOVÁ, H., LIPŠ, M., LINDNER, J., IVÁK, P., NETUKA, I., ŠEDIVÁ, B., HALUZÍK, M., KUZMA, M. Lipid Profiling in Epicardial and Subcutaneous Adipose Tissue of Patients with Coronary Artery Disease. Journal of proteome research, 2020, roč. 19, č. 10, s. 3993-4003. ISSN 1535-3893.cs
dc.identifier.issn1535-3893
dc.identifier.uri2-s2.0-85092681739
dc.identifier.urihttp://hdl.handle.net/11025/43635
dc.format11 s.cs
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.ispartofseriesJournal Of Proteome Researchen
dc.rightsPlný text není přístupný.cs
dc.rights© American Chemical Societyen
dc.titleLipid Profiling in Epicardial and Subcutaneous Adipose Tissue of Patients with Coronary Artery Diseaseen
dc.typečlánekcs
dc.typearticleen
dc.rights.accessclosedAccessen
dc.type.versionpublishedVersionen
dc.description.abstract-translatedCoronary artery disease is one of the most frequent causes of morbidity and mortality worldwide. It is even more prevalent in patients with type 2 diabetes mellitus who suffer from obesity and increased accumulation of epicardial fat with a possible contributing role in the development of coronary artery disease. We performed an MS-based lipidomic analysis of subcutaneous and epicardial adipose tissue in 23 patients with coronary artery disease stratified for the presence/absence of type 2 diabetes mellitus and a control group of 13 subjects aiming at identification of factors from epicardial fat contributing to the development of coronary artery disease. The samples of adipose tissues were obtained during elective cardiac surgery. They were extracted and analyzed with and without previous triacylglycerols separation by high-pressure liquid chromatography-mass spectrometry (HPLC-MS). Multi-variate and univariate analyses were performed. Lipidomics data were correlated with biochemical parameters. We identified multiple changes in monoacylglycerols, diacylglycerols, triacylglycerols, glycerophosphatidylserines, glycerophosphatidylethanolamines, glycerophosphatidylcholines, ceramides, sphingomyelins, and derivatives of cholesterol. Observed changes included molecules with fatty acids with odd (15:0, 15:1, 17:0, 17:1) and even (10:0, 12:0, 14:0, 16:0, 16:1, 18:0, 18:1, 18:2, 20:4, 20:1, 22:0) fatty acids in both types of adipose tissue. More pronounced changes were detected in epicardial adipose tissue compared to subcutaneous adipose tissue of patients with coronary artery disease and type 2 diabetes. Lipidomic analysis of subcutaneous and epicardial adipose tissue revealed different profiles for patients with coronary artery disease and type 2 diabetes, which might be related to coronary artery disease and the presence of type 2 diabetes.en
dc.subject.translatedepicardial adipose tissueen
dc.subject.translatedsubcutaneous adipose tissueen
dc.subject.translatedcoronary artery diseaseen
dc.subject.translatedtype 2 diabetes mellitusen
dc.subject.translatedlipidomicsen
dc.identifier.doi10.1021/acs.jproteome.0c00269
dc.type.statusPeer-revieweden
dc.identifier.document-number577157000011
dc.identifier.obd43930598
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