Title: TdP Incidence in Methoxamine-Sensitized Rabbit Model Is Reduced With Age but Not Influenced by Hypercholesterolemia
Authors: Aromolaran, Ademuyiwa S.
Nalos, Lukáš
Jarkovská, Dagmar
Švíglerová, Jitka
Süß, Annabell
Záleský, Jakub
Rajdl, Daniel
Krejčová, Milada
Kuncová, Jitka
Rosenberg, Josef
Štengl, Milan
Citation: NALOS, L., JARKOVSKÁ, D., ŠVÍGLEROVÁ, J., SÜß, A., ZÁLESKÝ, J., RAJDL, D., KREJČOVÁ, M., KUNCOVÁ, J., ROSENBERG, J., ŠTENGL, M., AROMOLARAN, AS. TdP Incidence in Methoxamine-Sensitized Rabbit Model Is Reduced With Age but Not Influenced by Hypercholesterolemia. Frontiers in Physiology, 2021, roč. 12, č. červen, s. 1-11. ISSN 1664-042X.
Issue Date: 2021
Publisher: Frontiers Media
Document type: článek
URI: 2-s2.0-85109135134
ISSN: 1664-042X
Keywords in different language: hypercholesterolemia, TdP arrhythmia, arrhythmia risk prediction, rabbit, amplitude-aware permutation entropy
Abstract in different language: Metabolic syndrome is associated with hypercholesterolemia, cardiac remodeling, and increased susceptibility to ventricular arrhythmias. Effects of diet-induced hypercholesterolemia on susceptibility to torsades de pointes arrhythmias (TdP) together with potential indicators of arrhythmic risk were investigated in three experimental groups of Carlsson’s rabbit model: (1) young rabbits (YC, young control, age 12–16 weeks), older rabbits (AC, adult control, age 20–24 weeks), and older age-matched cholesterol-fed rabbits (CH, cholesterol, age 20–24 weeks). TdP was induced by α-adrenergic stimulation by methoxamine and IKr block in 83% of YC rabbits, 18% of AC rabbits, and 21% of CH rabbits. High incidence of TdP was associated with high incidence of single (SEB) and multiple ectopic beats (MEB), but the QTc prolongation and short-term variability (STV) were similar in all three groups. In TdP-susceptible rabbits, STV was significantly higher compared with arrhythmia-free rabbits but not with rabbits with other than TdP arrhythmias (SEB, MEB). Amplitude-aware permutation entropy analysis of baseline ECG could identify arrhythmia-resistant animals with high sensitivity and specificity. The data indicate that the TdP susceptibility in methoxamine-sensitized rabbits is affected by the age of rabbits but probably not by hypercholesterolemia. Entropy analysis could potentially stratify the arrhythmic risk and identify the low-risk individuals.
Rights: © Frontiers Media
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