Title:	Analyzing histone modifications using tiled binned clustering and 3D scatter plots
Authors:	Zeckzer, Dirk Wiegreffe, Daniel Müller, Lydia
Citation:	Journal of WSCG. 2018, vol. 26, no. 1, p. 1-10.
Issue Date:	2018
Publisher:	Václav Skala - UNION Agency
Document type:	článek article
URI:	wscg.zcu.cz/WSCG2018/!_2018_Journal_WSCG-No-1.pdf http://hdl.handle.net/11025/34583
ISSN:	1213-6972 (print) 1213-6980 (CD-ROM) 1213-6964 (on-line)
Keywords:	shlukování;skládání;dlaždice;3D bodový diagram;biologická vizualizace;modifikace histonu
Keywords in different language:	clustering;binning;tiles;3D scatterplot;biological visualization;histone modifications
Abstract in different language:	A major goal in epigenetics is understanding how cells differentiate into different cell types. Besides the increase of individual data sets, the amount of replicated experiments generating a tremendous amount of data is ever increasing. While biologists primarily analyze their data on the highest level using statistical correlations or on the lowest level analyzing nucleotide sequences, determining the fate of histone modifications during cell specification necessitates improved analysis capabilities on one or more intermediate levels. For this type of analysis, it proved to be very useful to use tiled binned scatter plot matrices showing binary relationships or to use tiled binned 3D scatter plots showing ternary relationships. Quarternary or general n-ary relationships are not easily analyzable using visualization techniques like scatter plots, only. Therefore, we augmented existing clustering methods with the tiling and binning idea enabling the analysis of n-ary relationships. Analyzing the changes of histone modifications comparing two cell lines using tiled binned clustering, we found new, unknown relations in the data.
Rights:	© Václav Skala - UNION Agency
Appears in Collections:	Volume 26, Number 1 (2018)

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